Abstract:
:Antibodies have been prepared against the 2-oxoglutarate transport proteins purified from bovine heart and rat liver mitochondria. The anti-heart antiserum cross-reacts with the 2-oxoglutarate carrier (OGC) from beef, pig, rat and rabbit heart, but not with the OGC from liver of the same animals. Conversely, the anti-liver antiserum recognizes the carrier protein from liver of all species tested but not from heart. Immunoinactivation of oxoglutarate transport activity by the antibodies is also tissue specific. Peptide maps of purified OGC show structural differences between the carrier from heart and liver of the same animal species. These results indicate the existence of isoforms of the OGC in heart and liver.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Zara V,De Benedittis R,Ragan CI,Palmieri Fdoi
10.1016/0014-5793(90)81397-7subject
Has Abstractpub_date
1990-04-24 00:00:00pages
295-8issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(90)81397-7journal_volume
263pub_type
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