Abstract:
:Apolipoprotein E- (ApoE-) rich high-density lipoprotein (HDL), which was prepared from the bound fraction of normolipemic volunteers on heparin-Sepharose and from a hyperalphalipoproteinemic patient, potently inhibited aggregation of human platelets in a dose-dependent fashion. Dimyristoyl phosphatidylcholine liposome with apoE (apoE.DMPC) also inhibited platelet aggregation, and incubation of washed platelets with apoE.DMPC resulted in the release of cholesterol into the supernatant in a time- and dose-dependent manner. These results suggest that apoE plays a major role in the inhibitory effect of apoE-rich HDL in platelet function, presumably due to the release of cholesterol from the plasma membrane.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Higashihara M,Kinoshita M,Teramoto T,Kume S,Kurokawa Kdoi
10.1016/0014-5793(91)80449-dsubject
Has Abstractpub_date
1991-04-22 00:00:00pages
82-6issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(91)80449-Djournal_volume
282pub_type
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