Abstract:
:The control of physiological processes requires the regulation and coordination of many different signals and is determined in part by the activation and repression of expression of specific target genes. RIP140 is a ligand dependent coregulator of many nuclear receptors that influence such diverse processes as muscle metabolism, adipocyte and hepatocyte function, and reproduction. Recent evidence has shown that the ability of RIP140 to regulate nuclear receptor function is determined by the relative level of RIP140 expression in comparison with other cofactors, by post-translational modifications and by interactions with additional transcription factors. As a result it is becoming apparent that RIP140, via its interplay with other coregulators, plays a fundamental role in determining both the normal and pathogenic physiological state.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
White R,Morganstein D,Christian M,Seth A,Herzog B,Parker MGdoi
10.1016/j.febslet.2007.11.017subject
Has Abstractpub_date
2008-01-09 00:00:00pages
39-45issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(07)01161-1journal_volume
582pub_type
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