Role of ChREBP in hepatic steatosis and insulin resistance.

Abstract:

:Non-alcoholic fatty liver disease is tightly associated with insulin resistance, type 2 diabetes and obesity, but the molecular links between hepatic fat accumulation and insulin resistance are not fully identified. Excessive accumulation of triglycerides (TG) is one the main characteristics of non-alcoholic fatty liver disease and fatty acids utilized for the synthesis of TG in liver are available from the plasma non-esterified fatty acid pool but also from fatty acids newly synthesized through hepatic de novo lipogenesis. Recently, the transcription factor ChREBP (carbohydrate responsive element binding protein) has emerged as a central determinant of lipid synthesis in liver through its transcriptional control of key genes of the lipogenic pathway, including fatty acid synthase and acetyl CoA carboxylase. In this mini-review, we will focus on the importance of ChREBP in the physiopathology of hepatic steatosis and insulin resistance by discussing the physiological and metabolic consequences of ChREBP knockdown in liver of ob/ob mice.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Denechaud PD,Dentin R,Girard J,Postic C

doi

10.1016/j.febslet.2007.07.084

subject

Has Abstract

pub_date

2008-01-09 00:00:00

pages

68-73

issue

1

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(07)00875-7

journal_volume

582

pub_type

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