Abstract:
:Non-alcoholic fatty liver disease is tightly associated with insulin resistance, type 2 diabetes and obesity, but the molecular links between hepatic fat accumulation and insulin resistance are not fully identified. Excessive accumulation of triglycerides (TG) is one the main characteristics of non-alcoholic fatty liver disease and fatty acids utilized for the synthesis of TG in liver are available from the plasma non-esterified fatty acid pool but also from fatty acids newly synthesized through hepatic de novo lipogenesis. Recently, the transcription factor ChREBP (carbohydrate responsive element binding protein) has emerged as a central determinant of lipid synthesis in liver through its transcriptional control of key genes of the lipogenic pathway, including fatty acid synthase and acetyl CoA carboxylase. In this mini-review, we will focus on the importance of ChREBP in the physiopathology of hepatic steatosis and insulin resistance by discussing the physiological and metabolic consequences of ChREBP knockdown in liver of ob/ob mice.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Denechaud PD,Dentin R,Girard J,Postic Cdoi
10.1016/j.febslet.2007.07.084subject
Has Abstractpub_date
2008-01-09 00:00:00pages
68-73issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(07)00875-7journal_volume
582pub_type
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