Mitochondrial Ca2+ channels: Great unknowns with important functions.

Abstract:

:Mitochondria process local and global Ca(2+) signals. Thereby the spatiotemporal patterns of mitochondrial Ca(2+) signals determine whether the metabolism of these organelles is adjusted or cell death is executed. Mitochondrial Ca(2+) channels of the inner mitochondrial membrane (IMM) actually implement mitochondrial uptake from cytosolic Ca(2+) rises. Despite great efforts in the past, the identity of mitochondrial Ca(2+) channels is still elusive. Numerous studies aimed to characterize mitochondrial Ca(2+) uniport channels and provided a detailed profile of these great unknowns with important functions. This mini-review revisits previous research on the mechanisms of mitochondrial Ca(2+) uptake and aligns them with most recent findings.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Malli R,Graier WF

doi

10.1016/j.febslet.2010.01.010

subject

Has Abstract

pub_date

2010-05-17 00:00:00

pages

1942-7

issue

10

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(10)00027-X

journal_volume

584

pub_type

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