Abstract:
:Mitochondria process local and global Ca(2+) signals. Thereby the spatiotemporal patterns of mitochondrial Ca(2+) signals determine whether the metabolism of these organelles is adjusted or cell death is executed. Mitochondrial Ca(2+) channels of the inner mitochondrial membrane (IMM) actually implement mitochondrial uptake from cytosolic Ca(2+) rises. Despite great efforts in the past, the identity of mitochondrial Ca(2+) channels is still elusive. Numerous studies aimed to characterize mitochondrial Ca(2+) uniport channels and provided a detailed profile of these great unknowns with important functions. This mini-review revisits previous research on the mechanisms of mitochondrial Ca(2+) uptake and aligns them with most recent findings.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Malli R,Graier WFdoi
10.1016/j.febslet.2010.01.010subject
Has Abstractpub_date
2010-05-17 00:00:00pages
1942-7issue
10eissn
0014-5793issn
1873-3468pii
S0014-5793(10)00027-Xjournal_volume
584pub_type
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