Abstract:
:Ample evidence indicates that sphingosine-1-phosphate (SPP) can serve as an intracellular second messenger regulating calcium mobilization, and cell growth and survival. Moreover, the dynamic balance between levels of the sphingolipid metabolites, ceramide and SPP, and consequent regulation of opposing signaling pathways, is an important factor that determines whether a cell survives or dies. SPP has recently also been shown to be the ligand for the EDG-1 family of G-protein-coupled receptors, which now includes EDG-1, -3, -5, -6 and -8. SPP is thus a lipid mediator that has novel dual actions signaling inside and outside of the cell.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Spiegel S,Milstien Sdoi
10.1016/s0014-5793(00)01670-7keywords:
subject
Has Abstractpub_date
2000-06-30 00:00:00pages
55-7issue
1-2eissn
0014-5793issn
1873-3468pii
S0014-5793(00)01670-7journal_volume
476pub_type
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