Abstract:
:In human pancreatic islets an increase in the glucose concentration from 3 to 20 mM raised the free cytoplasmic Ca2+ concentration [( Ca2+]i), an effect being reversible upon withdrawal of the sugar. Depolarization with a high concentration of K+ or the sulphonylurea tolbutamide also raised [Ca2+]i. Addition of extracellular ATP produced a transient rapid rise in [Ca2+]i. Oscillations in [Ca2+]i were observed in the presence of 10 mM glucose. Insulinoma cells responded to glucose and tolbutamide with increases in [Ca2+]i, whereas the sulphonamide diazoxide caused a decrease in [Ca2+]i. These findings confirm previous results obtained in rodent beta-cells.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kindmark H,Köhler M,Nilsson T,Arkhammar P,Wiechel KL,Rorsman P,Efendić S,Berggren POdoi
10.1016/0014-5793(91)81309-vsubject
Has Abstractpub_date
1991-10-21 00:00:00pages
310-4issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(91)81309-Vjournal_volume
291pub_type
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