Hypotonic shocks activate rat TRPV4 in yeast in the absence of polyunsaturated fatty acids.


:Transient-receptor-potential channels (TRPs) underlie the sensing of chemicals, heat, and mechanical force. We expressed the rat TRPV1 and TRPV4 subtypes in yeast and monitored their activities in vivo as Ca(2+) rise using transgenic aequorin. Heat and capsaicin activate TRPV1 but not TRPV4 in yeast. Hypotonic shocks activate TRPV4 but not TRPV1. Osmotic swelling is modeled to activate enzyme(s), producing polyunsaturated fatty acids (PUFAs) to open TRPV4 in mammalian cells. This model relegates mechanosensitivity to the enzyme and not the channel. Yeast has only a single Delta9 fatty-acid monodesaturase and cannot make PUFAs suggesting an alternative mechanism for TRPV4 activation. We discuss possible explanations of this difference.




FEBS letters


Loukin SH,Su Z,Kung C




Has Abstract


2009-02-18 00:00:00














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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Lee KH,Na DS,Kim JW

    更新日期:1999-01-15 00:00:00

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    pub_type: 杂志文章


    authors: Domitrovic T,Fernandes CM,Boy-Marcotte E,Kurtenbach E

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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    pub_type: 信件


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    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    更新日期:1990-03-26 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Hamazaki H

    更新日期:1996-11-18 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Nguyen TM,Ellis JM,Ginjaar IB,van Paassen MM,van Ommen GJ,Moorman AF,Cartwright AJ,Morris GE

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    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Soares CM,Baptista AM

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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Morris RJ,Parkyn CJ,Jen A

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    journal_title:FEBS letters

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Chetverin AB

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Smigán P,Majerník A,Greksák M

    更新日期:1994-06-27 00:00:00