Abstract:
:Peroxisome proliferator-activated receptor gamma (PPARγ), a ligand-regulated nuclear hormone receptor, plays critical roles in metabolism and adipogenesis. PPARγ ligands such as thiazolidinediones (TZDs) exert insulin sensitizing and anti-inflammatory effects primarily through action on adipocytes, and are thus widely used to treat metabolic syndrome, especially type II diabetes. A number of PPARγ interacting partners have been identified, many of which are known epigenetic regulators, including enzymes for histone acetylation/deacetylation and histone methylation/demethylation. However, their functional roles in the PPARγ transcriptional pathway are not well defined. Recent advances in ChIP-based and deep sequencing technology are revealing previously underappreciated epigenomic mechanisms and therapeutic potentials of this nuclear receptor pathway.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sugii S,Evans RMdoi
10.1016/j.febslet.2011.05.007subject
Has Abstractpub_date
2011-07-07 00:00:00pages
2121-8issue
13eissn
0014-5793issn
1873-3468pii
S0014-5793(11)00349-8journal_volume
585pub_type
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