A single d(GpG) cisplatin adduct on the estrogen response element decreases the binding of the estrogen receptor.

Abstract:

:Both cisplatin and the estrogen receptor (ER) are known to bend DNA. The influence of the bending of sequences by the d(GpG)cisPt adduct binding of ER to estrogen response element (ERE)-like sequences was examined. Three ERE-like oligonucleotides with different affinities for ER and which include a GG in the linker sequence were designed in order to form a single central d(GpG)cisPt adduct. Using electrophoretic mobility shift assay and Scatchard analysis, it was shown that the presence of a single d(GpG)cisPt adduct in the linker sequence decreases the ER affinity for DNA. These results do not support a critical role of a DNA bend in the initial recognition of ERE by ER. Then, the platination of DNA outside of the ERE half-sites decreases the interaction of ER with ERE.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Massaad-Massade L,Massaad C,Legendre F,Bas V,Chottard J,Beaune P,Barouki R

doi

10.1016/s0014-5793(99)01755-x

keywords:

subject

Has Abstract

pub_date

2000-01-21 00:00:00

pages

49-53

issue

1

eissn

0014-5793

issn

1873-3468

pii

S001457939901755X

journal_volume

466

pub_type

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