Abstract:
:Uncoupling protein 3 (UCP3) is suggested to protect mitochondria against aging and lipid-induced damage, possibly via modulation of reactive oxygen species (ROS) production. Here we show that mice overexpressing UCP3 (UCP3Tg) have a blunted age-induced increase in ROS production, assessed by electron spin resonance spectroscopy, but only after addition of 4-hydroxynonenal (4-HNE). Mitochondrial function, assessed by respirometry, on glycolytic substrate was lower in UCP3Tg mice compared to wild types, whereas this tended to be higher on fatty acids. State 4o respiration was higher in UCP3Tg animals. To conclude, UCP3 overexpression leads to increased state 4o respiration and, in presence of 4-HNE, blunts the age-induced increase in ROS production.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Nabben M,Hoeks J,Briedé JJ,Glatz JF,Moonen-Kornips E,Hesselink MK,Schrauwen Pdoi
10.1016/j.febslet.2008.11.016subject
Has Abstractpub_date
2008-12-24 00:00:00pages
4147-52issue
30eissn
0014-5793issn
1873-3468pii
S0014-5793(08)00924-1journal_volume
582pub_type
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