Abstract:
:The physical properties of amino acids were investigated in order to evaluate their possible relationship to the assignment of codons for amino acids in the genetic code. A comparison of the interconversion probability between amino acids and the distances between the amino acids for individual physical properties revealed a striking hierarchy among the physical properties. Surprisingly, it is the long-range/solvent interactions and not the short-range/stereochemical properties which are preferentially conserved in the genetic code.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sitaramam Vdoi
10.1016/0014-5793(89)81237-2subject
Has Abstractpub_date
1989-04-10 00:00:00pages
46-50issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(89)81237-2journal_volume
247pub_type
杂志文章相关文献
FEBS LETTERS文献大全abstract::A new peptide, Tc1, containing only 23 amino acids closely packed by three disulfide bridges was isolated from the Amazonian scorpion Tityus cambridgei. It blocks reversibly the Shaker B K(+)-channels with a K(d) of 65 nM and displaces binding of noxiustoxin to mouse brain synaptosome membranes. It is the shortest kno...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(00)02253-5
更新日期:2000-12-08 00:00:00
abstract::The cytochrome bc(1) complex catalyzes electron transfer from ubiquinol to cytochrome c by a protonmotive Q cycle mechanism in which electron transfer is linked to proton translocation across the inner mitochondrial membrane. In the Q cycle mechanism proton translocation is the net result of topographically segregated...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1016/s0014-5793(03)00391-0
更新日期:2003-06-12 00:00:00
abstract::cDNAs encoding rat adipose tissue hormone-sensitive lipase were expressed in COS cells, under the control of the SV40 promoter to half the level in rat adipocytes, the richest native source of the enzyme. A cDNA lacking most of the long 5'-untranslated region of the full-length rat hormone-sensitive lipase cDNA was, w...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(91)80744-n
更新日期:1991-07-08 00:00:00
abstract::Transgenically introduced laminin (LN) alpha1 chain prevents muscular dystrophy in LNalpha2 chain deficient mice. We now report increased integrin alpha7Bbeta1D synthesis in dystrophic LNalpha2 chain deficient muscle. Yet, immunofluorescence demonstrated a reduced expression of integrin alpha7B subunit at the sarcolem...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2006.02.027
更新日期:2006-03-20 00:00:00
abstract::Three compounds with cytokinin activity have been isolated from the medium of Rhodospirillum rubrum grown photosynthetically. Two N-6 aminopurine cytokinins revealed in the medium were identical with those obtained from R. rubrum cells previously. The third compound with cytokinin activity in Amaranthus caudatus bioas...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(95)00430-h
更新日期:1995-05-22 00:00:00
abstract::In contrast to the preponderance of affected males in families with X-linked mental retardation, Rett syndrome (RTT) is a neurological disorder occurring almost exclusively in females. The near complete absence of affected males in RTT families has been explained by the lethal effect of an X-linked gene mutation in he...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(00)01994-3
更新日期:2000-09-22 00:00:00
abstract::Amyloid precursor protein (APP) gene expression was investigated in primary cultures of neurons, astrocytes, microglial cells and oligodendrocytes. Neurons from various rat brain regions, as well as oligodendrocytes, contained RNA encoding APP695, while astrocytes and microglial cells expressed high levels of RNAs for...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(92)80706-m
更新日期:1992-08-03 00:00:00
abstract::The nucleotide sequence of the Pseudomonas saccharophila gene encoding maltotetraohydrolase (G4-forming amylase) has been determined. The coding region for the G4-forming amylase precursor contained 1653 nucleotides. The deduced precursor protein included an N-terminal 21-residue putative signal peptide; the deduced m...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(89)81056-7
更新日期:1989-09-11 00:00:00
abstract::10Sa RNA is a bacterial small stable RNA, in which the 5'- and 3'-end sequences are folded into a tRNA-like structure. The RNA accepts alanine in vitro, and interacts with 70S ribosomes in the cells. In this study, we examined the ribosome-binding properties of Escherichia coli 10Sa RNA in vivo, and found that the ami...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(96)01330-0
更新日期:1996-12-16 00:00:00
abstract::A homogenate of purified chromaffin cells was fractionated, after removal of the nuclear fraction, by sucrose density gradient ultracentrifugation. The presence and subcellular localization of low molecular mass GTP-binding proteins was explored by incubation of blots of proteins from different subcellular fractions w...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(89)81254-2
更新日期:1989-04-10 00:00:00
abstract::We have previously identified the binding region of a new Ca2+ antagonist semotiadil in the skeletal muscle Ca2+ channel. To the same semotiadil derivatives, the cardiac counterpart showed distinct and different binding characteristics: semotiadil and its photoaffinity analog D51-4700 inhibited [3H]PN200-110 binding t...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(98)01536-1
更新日期:1998-12-11 00:00:00
abstract::Structural integrity may be needed for the glutathione-linked peroxidase activity of human ceruloplasmin. Intact human ceruloplasmin has a potent peroxidase property to decompose H2O2 in the presence of reduced glutathione. However, the fragment of approximately 116000 Da produced by proteolytic degradation had less t...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(98)01253-8
更新日期:1998-10-23 00:00:00
abstract::In this study, we demonstrated that Ent-11alpha-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F) had stronger cytotoxicity against MKN-45, a gastric cancer cell line bearing wild-type p53 than MKN-28, another gastric cancer cell line containing missense mutation in p53. The rapid increase of ROS level was involved in the me...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2005.01.050
更新日期:2005-02-28 00:00:00
abstract::There are numerous examples of how fundamental research has been required to understand and treat human disease. This article focuses on three human diseases of lipid metabolism in which advancements in understanding and treatment would not have been possible without basic research. Fabry disease is an inherited metab...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1016/j.febslet.2006.06.025
更新日期:2006-10-09 00:00:00
abstract::The fibroblast growth factor receptor substrate (FRS)-2 protein family comprises FRS2alpha, a well-known central mediator for fibroblast growth factor signaling, and FRS2beta, whose endogenous expression pattern and function are not yet defined. Immunohistochemical analysis revealed that expression of FRS2beta was res...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2009.01.042
更新日期:2009-02-18 00:00:00
abstract::We report a new method for the detection of ligand-induced receptor internalization by fluorescence ratiometric imaging of pH in endosomes in combination with a recently developed posttranslational labeling system based on the formation of a heterodimeric coiled-coil structure. The N-terminus of the β2-adrenergic rece...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2011.06.012
更新日期:2011-07-21 00:00:00
abstract::The type 1 ribosome-inactivating protein (RIP) saporin 5 isolated from seeds of Saponaria officinalis L. strongly inhibited translation carried out by Vicia sativa L. purified ribosomes. The toxin multidepurinated V. sativa rRNA, which upon treatment with acid aniline releases several RNA fragments including an RNA fr...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(93)81091-d
更新日期:1993-07-05 00:00:00
abstract::The higher-order structure of G protein-coupled receptors (GPCRs) in membranes may involve dimerization and formation of even larger oligomeric complexes. Here, we have investigated the organization of the prototypical GPCR rhodopsin in its native membrane by electron and atomic force microscopy (AFM). Disc membranes ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/S0014-5793(04)00194-2
更新日期:2004-04-30 00:00:00
abstract::Four 12.2-12.6 kDa small heat-shock proteins (sHSPs) of Caenorhabditis elegans are the smallest known members of the sHSP family. They essentially comprise the characteristic C-terminal 'alpha-crystallin domain' of the sHSPs, having a very short N-terminal region, and lacking a C-terminal tail. Recombinant Hsp12.2 and...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(98)00917-x
更新日期:1998-08-21 00:00:00
abstract::The N-terminal processing of MADH from the bacterium T. versutus and the N-terminal heterogeneity of the isolated alpha subunit of the alpha 2 beta 2 protein complex was demonstrated by a combination of Edman sequence analysis of an electroblotted band, in situ digested with pyroglutamate aminopeptidase, and accurate ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(93)80402-g
更新日期:1993-10-25 00:00:00
abstract::Chromatin phospholipidic fraction, as previously demonstrated, shows the same localization as RNA inside the nuclei. DNase and RNase treatment of nuclei removed almost totally the DNA, 63% of RNA and caused a 50% loss of phospholipids. The aim of the present investigation is to study the fraction of RNase undigested n...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(98)00810-2
更新日期:1998-07-24 00:00:00
abstract::The use of oryzacystatins I and II, two cysteine proteinase inhibitors naturally produced in rice grains, represents an attractive way for the control of Coleoptera insect pests. The present study was done to analyze the inhibitory effect of recombinant oryzacystatins produced in Escherichia coli as fusion proteins ag...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(93)80320-t
更新日期:1993-09-27 00:00:00
abstract::Acute hyperammonemia, induced by two consecutive injections of ammonium acetate (550 and 450 mg per kg b.wt.), decreased the activity of gamma-glutamyl transpeptidase (GGT) in most brain regions of 18- and 30-day-old rats. This decrease in the brain GGT activity was more pronounced in younger than in older rats. After...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(92)80855-b
更新日期:1992-04-06 00:00:00
abstract::Aah VI was isolated from the venom of the North African scorpion, Androctonus australis hector. It is the first glycosylated neurotoxin from scorpion venom to be described. It was not toxic to mice, when injected intracerebroventricularly at a dose of 1.2 microg per animal. However, it had typical activity in Blatella...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(98)01710-4
更新日期:1999-01-25 00:00:00
abstract::A cDNA encoding stromal ascorbate peroxidase (sAPX) was isolated using poly(A)+ RNA of pumpkin cotyledons by RT-PCR. The cDNA encodes a polypeptide with 372 amino acids and shares complete sequence identity with pumpkin thylakoid-bound ascorbate peroxidase (tAPX), except for the deletion of a putative membrane spannin...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(97)00862-4
更新日期:1997-08-11 00:00:00
abstract::The post-translational modification of histone proteins plays an important role in controlling cell fate by directing essentially all DNA-associated nuclear processes. Misregulation and mutation of histone modifying enzymes is a hallmark of tumorigenesis. However, how these different epigenetic modifications lead to t...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1016/j.febslet.2012.04.002
更新日期:2012-06-04 00:00:00
abstract::Phosphatidylinositol transfer proteins (PITP) are abundant cytosolic proteins originally identified because of their ability to act in vitro as specific transporters of phosphatidylinositol or phosphatidylcholine between membranes. However, the cellular function of mammalian PITP has remained enigmatic till recently. ...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1016/s0014-5793(97)00414-6
更新日期:1997-06-23 00:00:00
abstract::We examined the role of p38 mitogen-activated protein (MAP) kinase in the tumor necrosis factor alpha (TNF-alpha)- or interleukin-1beta (IL-1beta)-induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast (RSF) cultures concomitantly with the induction of p38 MAP kinas...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(99)01717-2
更新日期:2000-01-07 00:00:00
abstract::In plants exposed to high irradiances of visible light, the D1 protein in the reaction center of photosystem II is oxidatively damaged and rapidly degraded. Earlier work in our laboratory showed that the serine protease Deg2 performs the primary cleavage of photodamaged D1 protein in vitro. Here, we demonstrate that t...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2006.11.058
更新日期:2006-12-22 00:00:00
abstract::Filamin plays an important role in actin cytoskeleton organization, membrane stabilization, and anchoring of transmembrane proteins. Using short interfering RNA (siRNA) to selectively target the filamin A gene and silence its expression, we studied the role of filamin A in G protein coupled receptor (GPCR) signaling. ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2006.02.035
更新日期:2006-03-20 00:00:00