Abstract:
:TATA-box binding factor TFIID is one of the key factors in transcriptional activation. Surprisingly, the yeast TFDII protein [(1989) Nature 341, 299-303; (1989) Cell 56, 1173-1181; (1989) Proc. Natl. Acad. Sci USA 86, 7785-7789] reveals only limited homology with other DNA-binding proteins. From computer-assisted searches we infer that yeast TFIID possesses a domain structure in which homologous segments are repeated. The greatest similarity is found between two segments, each 33 amino acids in length, in which the positions of four basic residues are strictly conserved. The high homology is also reflected at the gene level. Implications of this novel type of domain structure for possible interactions in transcriptional activation are discussed.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Stucka R,Feldmann Hdoi
10.1016/0014-5793(90)80558-zsubject
Has Abstractpub_date
1990-02-26 00:00:00pages
223-5issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(90)80558-Zjournal_volume
261pub_type
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