Abstract:
:The kinetics of the tRNA cycle is in itself capable of keeping the translational error level almost unaffected by amino acid starvation. There is no need to assume any yet unknown mechanism or property. Kinetic analysis shows that the concentration of aminoacyl-tRNA can stay high even for large reductions in aminoacylation, since the pool of uncharged tRNA normally is very small. An enhanced binding of uncharged tRNA to the ribosome could increase the effect and produce an extremely efficient error damping. A similar result is obtained when EF-Tu is partially inhibited by ppGpp.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Liljenström Hdoi
10.1016/0014-5793(87)80498-2subject
Has Abstractpub_date
1987-10-19 00:00:00pages
1-5issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(87)80498-2journal_volume
223pub_type
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