Abstract:
:JAK2 V617F mutant induces transformation through aberrant activation of various transcription factors. We found that the expression of Aurora kinase A (Aurka) was significantly induced by mutant JAK2 through c-Myc expression. Interestingly, mutant JAK2 enhanced resistance to cisplatin (CDDP)-induced DNA damage, and effectively suppressed apoptosis. Ectopic expression of Aurka in Ba/F3 cells exhibited similar resistance to CDDP, and this required kinase activity. Conversely, knockdown and inhibition of Aurka in cells expressing mutant JAK2 abolished the resistance to CDDP. Taken together, Aurka is most likely critical for resistance to DNA damage in cells transformed by JAK2 V617F mutant.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sumi K,Tago K,Kasahara T,Funakoshi-Tago Mdoi
10.1016/j.febslet.2011.04.068subject
Has Abstractpub_date
2011-06-23 00:00:00pages
1884-90issue
12eissn
0014-5793issn
1873-3468pii
S0014-5793(11)00338-3journal_volume
585pub_type
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