Abstract:
:The effect of increasing low density lipoprotein (LDL) concentrations on the synthesis of basement membrane components was investigated in proliferating porcine aortic endothelial cells (PAEC) in culture. Basement membrane-associated heparan sulfate proteoglycan (HSPG) and fibronectin were determined by enzyme immunoassay. Low extracellular LDL-levels increase, high extracellular LDL-levels decrease the HSPG content of PAEC. Fibronectin synthesis was only slightly affected while proliferation and metabolic activity as assessed by lactate production were constant. Insulin or high extracellular glucose did not influence the effect of LDL on basement membrane components.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Olgemöller B,Schleicher ED,Schwaabe S,Guretzki HJ,Gerbitz KDdoi
10.1016/0014-5793(90)80758-bsubject
Has Abstractpub_date
1990-05-07 00:00:00pages
37-9issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(90)80758-Bjournal_volume
264pub_type
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