Abstract:
:The concentration of insulin that produces half-maximal stimulation of glycolysis by stripped soleus muscle preparations is markedly increased by the adenosine analogues, 2-chloroadenosine and N6-phenylisopropyladenosine, but is markedly decreased by the methyl xanthine analogue, 8-phenyltheophylline. 2-Chloroadenosine increases the concentration of insulin required to stimulate glycolysis half maximally, from about 100 to 2000 mu units/ml. 8-Phenyltheophylline decreases this concentration of insulin from about 100 to 10 mu units/ml, an effect which is similar to that produced either by addition of adenosine deaminase to the medium or to exercise-training of the donor animals for 4 weeks.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Budohoski L,Challiss RA,McManus B,Newsholme EAdoi
10.1016/0014-5793(84)80820-0subject
Has Abstractpub_date
1984-02-13 00:00:00pages
1-4issue
1eissn
0014-5793issn
1873-3468journal_volume
167pub_type
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