Effects of analogues of adenosine and methyl xanthines on insulin sensitivity in soleus muscle of the rat.

Abstract:

:The concentration of insulin that produces half-maximal stimulation of glycolysis by stripped soleus muscle preparations is markedly increased by the adenosine analogues, 2-chloroadenosine and N6-phenylisopropyladenosine, but is markedly decreased by the methyl xanthine analogue, 8-phenyltheophylline. 2-Chloroadenosine increases the concentration of insulin required to stimulate glycolysis half maximally, from about 100 to 2000 mu units/ml. 8-Phenyltheophylline decreases this concentration of insulin from about 100 to 10 mu units/ml, an effect which is similar to that produced either by addition of adenosine deaminase to the medium or to exercise-training of the donor animals for 4 weeks.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Budohoski L,Challiss RA,McManus B,Newsholme EA

doi

10.1016/0014-5793(84)80820-0

subject

Has Abstract

pub_date

1984-02-13 00:00:00

pages

1-4

issue

1

eissn

0014-5793

issn

1873-3468

journal_volume

167

pub_type

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