Abstract:
:In this work, we examined the antioxidant role of mucin, a typical sialic acid containing high-molecular weight glycoprotein. The function of mucin as a hydroxyl radical (.OH) scavenger was characterized using bovine submaxillary gland mucin (BSM). Non-treated BSM effectively protected DNA from the attack of .OH; however, desialylated BSM lost this potential. Moreover, we estimated the scavenging effects of BSM against .OH generated by UV irradiation of hydrogen peroxide using ESR analysis. Our results indicate that BSM has .OH scavenging ability the and sialic acid in mucin is an essential moiety to scavenge .OH.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Ogasawara Y,Namai T,Yoshino F,Lee MC,Ishii Kdoi
10.1016/j.febslet.2007.04.062subject
Has Abstractpub_date
2007-05-29 00:00:00pages
2473-7issue
13eissn
0014-5793issn
1873-3468pii
S0014-5793(07)00458-9journal_volume
581pub_type
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