Abstract:
:The ATP synthase capacity of rat heart myocytes can be measured in sonicates of cultured cardiomyocytes. In these cells, transitions in ATP synthase capacity occur on changing to the anoxic or uncoupled state (drop in ATP synthase capacity of over 40%) or on electrically stimulating the cells to contract (rise of 70%). These changes occur rapidly (half time less than 1 min) and are completely reversed on returning to the original conditions. It is proposed that mitochondria in vivo are directly regulated at the level of the ATP synthase. The naturally occurring inhibitor protein from mitochondria may be responsible for this regulation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Das AM,Harris DAdoi
10.1016/0014-5793(89)81725-9subject
Has Abstractpub_date
1989-10-09 00:00:00pages
97-100issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(89)81725-9journal_volume
256pub_type
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