Abstract:
:Mitochondrial uncoupling protein 2 (UCP2) is abundant in developing monocyte/macrophage cells and may affect hematopoiesis by reducing formation of reactive oxygen species. The aims of this study were to further characterize the involvement of UCP2 in hematopoiesis. In situ hybridization in mouse embryos identified UCP2-positive cells in liver and inside primitive blood vessels from 10.5 days of prenatal development. High UCP2 transcript levels were detected in reticulocytes and other maturating erythroid cells in peripheral blood of mice exposed to hypoxia, and in umbilical cord blood of human neonates and peripheral blood of adults. Our results suggest involvement of UCP2 in erythropoiesis.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Flachs P,Sponarova J,Kopecky P,Horvath O,Sediva A,Nibbelink M,Casteilla L,Medrikova D,Neckar J,Kolar F,Kopecky Jdoi
10.1016/j.febslet.2007.02.012subject
Has Abstractpub_date
2007-03-20 00:00:00pages
1093-7issue
6eissn
0014-5793issn
1873-3468pii
S0014-5793(07)00157-3journal_volume
581pub_type
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