Abstract:
:5(S)-Hydroxyicosatetraenoate stimulates human polymorphonuclear neutrophils (PMNs) to raise their cytosolic calcium. It also potentiates the cells' degranulation responses to platelet-activating factor and diacylglycerols. We synthesized 5(R)-hydroxyicosatetraenoate and found it to be 20-100-fold weaker than the natural isomer in these assays. Thus, the arachidonic acid metabolite activates PMNs by a stereospecific possibly receptor-mediated mechanism.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Rossi AG,Thomas MJ,O'Flaherty JTdoi
10.1016/0014-5793(88)80360-0subject
Has Abstractpub_date
1988-11-21 00:00:00pages
163-6issue
1-2eissn
0014-5793issn
1873-3468journal_volume
240pub_type
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