Abstract:
:HGTD-P is a hypoxia-responsive pro-apoptotic protein that transmits hypoxic signals directly to mitochondria. When overexpressed, HGTD-P induces cell death via typical mitochondrial apoptotic cascades. However, much is unknown about post-transcriptional modification and signaling networks of HGTD-P in association with cell death-regulating proteins. We performed yeast two-hybrid screening to identify the molecules involved in HGTD-P-mediated cell death pathways. In this study, we show that heat shock protein 90 physically interacts with HGTD-P and that suppression of Hsp90 activity by low concentrations of geldanamycin reduced HGTD-P-induced mitochondrial catastrophe through inhibition of mitochondrial translocation of HGTD-P.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kim JY,Kim SM,Ko JH,Yim JH,Park JH,Park JHdoi
10.1016/j.febslet.2006.05.001subject
Has Abstractpub_date
2006-05-29 00:00:00pages
3270-5issue
13eissn
0014-5793issn
1873-3468pii
S0014-5793(06)00543-6journal_volume
580pub_type
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