Abstract:
:The tetraspanins associate with various surface molecules and with each other to build a network of molecular interactions, the tetraspanin web. The interaction of tetraspanins with each other seems to be central for the assembly of the tetraspanin web. All tetraspanins studied, CD9, CD37, CD53, CD63, CD81, CD82 and CD151, were found to incorporate [3H]palmitate. By site-directed mutagenesis, CD9 was found to be palmitoylated at any of the four internal juxtamembrane regions. The palmitoylation of CD9 did not influence the partition in detergent-resistant membranes but contributed to the interaction with CD81 and CD53. In particular, the resistance of the CD9/CD81 interaction to EDTA, which disrupts other tetraspanin/tetraspanin interactions, was entirely dependent on palmitoylation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Charrin S,Manié S,Oualid M,Billard M,Boucheix C,Rubinstein Edoi
10.1016/s0014-5793(02)02522-xkeywords:
subject
Has Abstractpub_date
2002-04-10 00:00:00pages
139-44issue
1-3eissn
0014-5793issn
1873-3468pii
S001457930202522Xjournal_volume
516pub_type
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