Abstract:
:50 S ribosomal subunit derivatives without the 5 S RNA-protein complex obtained either by splitting with EDTA or by reconstitution from the 23 S RNA and proteins have been studied by electron microscopy. Removal of the 5 S RNA-protein complex is shown to affect neither the overall morphology of the larger ribosomal subunit nor the mode of its association with the small subunit.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Selivanova OM,Gongadze GM,Gudkov AT,Vasiliev VDdoi
10.1016/0014-5793(86)80302-7subject
Has Abstractpub_date
1986-03-03 00:00:00pages
79-83issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(86)80302-7journal_volume
197pub_type
杂志文章相关文献
FEBS LETTERS文献大全abstract::A link between alterations in cholesterol homeostasis and Alzheimer's disease (AD) is nowadays widely accepted. However, the molecular mechanism/s underlying such link remain unclear. Numerous experimental evidences support the view that changes in neuronal membrane cholesterol levels and/or subcellular distribution d...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1016/j.febslet.2006.06.038
更新日期:2006-10-09 00:00:00
abstract::Ballistic transfection, based on cell and tissue bombardment by the tungsten and gold microparticles covered with the gene DNA, was used for the delivery of a bacterial beta-galactosidase and a full-length cDNA copy of the human dystrophin genes into mouse skeletal muscles. CMV-lacZ, SV40-lacZ, LTR-lacZneo and full-le...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(97)01019-3
更新日期:1997-09-08 00:00:00
abstract::Inositol 1,4,5-trisphosphate (1,4,5-InsP3) was perfused into rat dorsal root ganglion (DRG) neurons by whole-cell patch-clamp electrodes, while measuring the membrane potential. This operation evoked a transient (2-3 min) membrane hyperpolarization of about -15 mV (from -42 mV) followed by a depolarization. The membra...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(92)80602-d
更新日期:1992-06-15 00:00:00
abstract::Ceramide-1-phosphate (CER-1-P) is emerging as a novel bioactive sphingolipid. It is formed by phosphorylation of ceramide catalyzed by ceramide kinase, and has been implicated in different cellular processes. Cer-1-P is mitogenic for fibroblasts, blocks apoptosis in macrophages, controls phagocytosis in neutrophils, a...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1016/s0014-5793(04)00211-x
更新日期:2004-03-26 00:00:00
abstract::In cardiac cells the effects of n-3 PUFAs on the whole genome are still unknown despite their recognized cardioprotective effects and ability to modulate gene expression. We have evaluated the effects of n-3 PUFAs supplementation on the global gene expression profile in cultured neonatal rat cardiomyocytes, detecting ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2007.01.070
更新日期:2007-03-06 00:00:00
abstract::At alpha 1-adrenergic receptors in isolated rat liver parenchymal cells, (-)-epinephrine is potent in eliciting a maximal increase in glycogenolysis (Kact = 24 nM). This contrasts with a 100-fold lower affinity for the agonist at alpha 1-adrenergic receptors of intact hepatocytes determined from equilibrium competitio...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(85)81243-6
更新日期:1985-08-05 00:00:00
abstract::Perturbation of the aerobic steady-state in a chemostat culture of the ethanol-producing bacterium Zymomonas mobilis with a small pulse of ethanol causes a burst of ethanol oxidation, although the reactant ratio of the alcohol dehydrogenase (ADH) reaction ([NADH][acetaldehyde][H(+)])/([ethanol][NAD(+)]) remains above ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2006.08.034
更新日期:2006-09-18 00:00:00
abstract::Focal adhesion (FA) proteins, kindlin-2 and integrin-linked kinase (ILK), regulate cell adhesion and migration. ILK interacts with and promotes kindlin-2 targeting to FAs. Leu353 and Leu357 in kindlin-2 have been reported to be important for the interaction between kindlin-2 and ILK. However, the binding interface bet...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.12938
更新日期:2018-01-01 00:00:00
abstract::The phosphate transporter Pho84 of Saccharomyces cerevisiae is predicted to contain 12 transmembrane (TM) regions, divided into two partially duplicated parts of 6 TM segments. The three-dimensional (3D) organization of the Pho84 protein has not yet been determined. However, the 3D crystal structure of the Escherichia...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2004.11.012
更新日期:2004-12-17 00:00:00
abstract::The band 3 protein-mediated, valinomycin-induced KCl efflux continues to increase with increasing [KCl] when the Cl-/Cl- equilibrium exchange becomes saturated. This suggests the existence of a band 3-mediated component of Cl- flux that contributes to the electrical conductance without being related to slippage; i.e.,...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(83)80272-5
更新日期:1983-05-30 00:00:00
abstract::Treatment of the chemically transformed fibroblasts BP-A31 and other cell lines with low concentrations of cycloheximide (CHM) for 72 h followed by the removal of the protein synthesis inhibitor leads to the proliferation of alpha-difluoromethylornithine (DFMO)-resistant phenotypes. These drug-resistant cells contain ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(86)81349-7
更新日期:1986-09-29 00:00:00
abstract::We previously have shown that the overexpression of phospholipase C-gamma1 (PLC-gamma1) in rat 3Y1 fibroblasts results in malignant transformation (Chang, J.-S., Noh, D.Y., Park, I.A., Kim, M;.J., Song, H., Ryu, S.H. and Suh, P.-G. (1997) Cancer Res. 57, 5465-5468). The transformed cells, which initially are in an elo...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(99)01338-1
更新日期:1999-10-22 00:00:00
abstract::Tumor suppressor WW domain-containing oxidoreductase (WWOX) is depleted in various cancer types. Here we report that WWOX is modified by small ubiquitin-like modifier (SUMO) proteins and represses DU145 prostate cancer tumorigenesis in a SUMOylation-dependent manner. Ectopic WWOX was shown to associate with SUMO2/3 or...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2015.11.028
更新日期:2015-12-21 00:00:00
abstract::Monoamine oxidase B (MAO B) is an outer mitochondrial membrane protein that oxidizes arylalkylamine neurotransmitters and has been a valuable drug target for many neurological disorders. The 1.7 angstrom resolution structure of human MAO B shows the enzyme is dimeric with a C-terminal transmembrane helix protruding fr...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1016/S0014-5793(04)00209-1
更新日期:2004-04-30 00:00:00
abstract::During steady-state, the Pi released in the medium is derived from glucose-6-phosphate which continuously regenerates the ATP hydrolyzed. A membrane potential (delta psi) can be built up in submitochondrial particles using glucose-6-phosphate and hexokinase as an ATP-regenerating system. The energy derived from the me...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(92)81273-o
更新日期:1992-08-17 00:00:00
abstract::Cap-independent translation (CIT) occurs at the leader sequences of uncapped plant viral RNAs, but also at a number of normally capped cellular mRNAs and has been correlated with sequence complementarity to 18S rRNA. The ribosomal protein S18 (RPS18) is a component of the small ribosomal subunit and is encoded by thre...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2006.04.012
更新日期:2006-05-15 00:00:00
abstract::The carbohydrate chains of the pathological human immunoglobulins M from two patients with Waldenström's macroglobulinemia were released by hydrazinolysis. The N-acetyllactosamine-type glycans were obtained by affinity chromatography on concanavalin A and fractionated by high-voltage paper electrophoresis. The primary...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(84)81341-1
更新日期:1984-05-21 00:00:00
abstract::Cellular retinoic acid binding proteins (CRABPs) bind all-trans-retinoic acid (atRA) tightly. This study aimed to determine whether atRA is channeled directly to cytochrome P450 (CYP) CYP26B1 by CRABPs, and whether CRABPs interact directly with CYP26B1. atRA bound to CRABPs (holo-CRABP) was efficiently metabolized by ...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.12303
更新日期:2016-08-01 00:00:00
abstract::The amino acid sequence of protein Z has been determined from sequence analysis performed on fragments obtained by chemical and enzymatic degradations. The polypeptide consists of a single chain containing 396 amino acid residues (Mr 43 677). Comparison with the vitamin K-dependent plasma proteins reveals an extensive...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(85)80633-5
更新日期:1985-05-20 00:00:00
abstract::This review focuses on the factors that regulate the proliferation of pancreatic islet beta-cells in vitro, and in particular on the intracellular pathways that convey the mitogenic signal into a proliferative response. Substances as diverse as nutrients, polypeptides, cytokines, adrenergic agents, lithium, phorbol es...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1016/0014-5793(92)81373-t
更新日期:1992-10-19 00:00:00
abstract::The transdifferentiation of hepatic stellate cells into myofibroblast-like cells and the proliferation of the transdifferentiated cells are controlled by TGF-beta1. Little is known about the intracellular signal transducers of TGF-beta1. In this paper we show that in cultured hepatic stellate cells TGF-beta1 induces a...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(97)00024-0
更新日期:1997-02-10 00:00:00
abstract::Snake venoms are rich sources of serine proteinase inhibitors that are members of the Kunitz/BPTI (bovine pancreatic trypsin inhibitor) family. However, only a few of their gene sequences have been determined from snakes. We therefore cloned the cDNAs for the trypsin and chymotrypsin inhibitors from a Vipera ammodytes...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(03)00693-8
更新日期:2003-07-17 00:00:00
abstract::Selenium-dependent glutathione peroxidase activity is documented for the first time in insects. Reduction in glutathione peroxidase activity in the cytosol of adult house flies by lowering selenium in the diet results in significant increases in peroxidative injury. Catalase activity, while higher in low-selenium flie...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(87)81056-6
更新日期:1987-06-29 00:00:00
abstract::Polypeptides rich in glutamic acid are strong inhibitors purified from isolated nuclei of Xenopus laevis oocytes of casein kinase II. The presence of tyrosine in these peptides greatly enhances their inhibitory capacity. Using casein as a substrate, copolyglu:tyr (4:1) has an I50 value of 20 nM, 250 fold lower than th...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(90)80897-r
更新日期:1990-06-04 00:00:00
abstract::Adenosine and ATP modulate cellular and tissue functions via specific P1 and P2 receptors, respectively. Although, in general, adenosine inhibits excitability and ATP functions as an excitatory transmitter in the central nervous system, little is known about the direct interaction between P1 and P2 receptors. We recen...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(02)03540-8
更新日期:2002-11-06 00:00:00
abstract::The essential role of Factor VIII:C (FVIII:C, anti-hemophilia factor A) as a cofactor for Factor IXa-dependent activation of Factor X has been established. In this paper, we describe that capillary endothelial cells from bovine adrenal medulla express active FVIII:C gene. Accumulation of FVIII:C in conditioned media f...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(92)80831-z
更新日期:1992-07-13 00:00:00
abstract::The interaction of the adrenoleukodystrophy protein (ALDP), mutated in the peroxisomal disorder X-linked adrenoleukodystrophy, and the very long-chain acyl-CoA synthetase (VLACS), the enzyme whose function is missing in this disease, remains obscure. As a first step to studying this interaction in wild type versus ALD...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(98)00255-5
更新日期:1998-03-27 00:00:00
abstract::Immunoprecipitated p100Gag-Mil protein kinase from MH2-transformed quail embryo fibroblasts is associated with an 89 kDa protein. The molar ratio between p89 and Gag-Mil in the immunocomplex is 0.72, indicating that the majority of Gag-Mil is complexed with p89. During mitosis part of Gag-Mil is shifted to a form with...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(94)80598-9
更新日期:1994-04-18 00:00:00
abstract::The mediator complex in the RNA polymerase II holoenzyme is known to be involved in transcriptional activation. The role of the essential mediator component Srb7p has been difficult to investigate, since no conditional lethal allele has been available to date. While the expression of Srb7p under the control of a repre...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(00)02123-2
更新日期:2000-10-27 00:00:00
abstract::A novel protein that binds specifically to the intracellular domain of the p55 tumor necrosis factor (TNF) receptor was cloned by two-hybrid screening of a HeLa cell cDNA library. Data bank searches revealed high sequence similarity of the protein (55.11) to yeast, nematode and plant proteins, whose functions are yet ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(95)00534-g
更新日期:1995-06-19 00:00:00