Abstract:
:A novel protein that binds specifically to the intracellular domain of the p55 tumor necrosis factor (TNF) receptor was cloned by two-hybrid screening of a HeLa cell cDNA library. Data bank searches revealed high sequence similarity of the protein (55.11) to yeast, nematode and plant proteins, whose functions are yet unknown. Significant similarity was also found between 55.11 and SEN3, the yeast equivalent of the p112 subunit of the 26S proteasome. Deletion analysis showed that the protein binds to the p55 receptor upstream to the region involved in induction of cell death.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Boldin MP,Mett IL,Wallach Ddoi
10.1016/0014-5793(95)00534-gsubject
Has Abstractpub_date
1995-06-19 00:00:00pages
39-44issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(95)00534-Gjournal_volume
367pub_type
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