Abstract:
:We report that sodium butyrate, a natural product of fiber degradation by colonic bacteria, markedly suppresses c-Myc-mediated apoptosis induced in murine plasmacytomas and human Burkitt lymphomas by growth factor deprivation, but not in cell lines devoid of c-myc translocations. Attenuation of cell death is associated with downregulation of the rearranged c-myc and activation of pRb via its dephosphorylation. We suggest that in vivo sodium butyrate may play an important role in plasmacytomagenesis by supporting the survival of cells with c-myc translocations, which otherwise would be eliminated by the lack of growth factors.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Alexandrov I,Romanova L,Mushinski F,Nordan Rdoi
10.1016/s0014-5793(98)00926-0subject
Has Abstractpub_date
1998-08-28 00:00:00pages
209-14issue
1-2eissn
0014-5793issn
1873-3468pii
S0014-5793(98)00926-0journal_volume
434pub_type
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