Abstract:
:Ceramide-1-phosphate (CER-1-P) is emerging as a novel bioactive sphingolipid. It is formed by phosphorylation of ceramide catalyzed by ceramide kinase, and has been implicated in different cellular processes. Cer-1-P is mitogenic for fibroblasts, blocks apoptosis in macrophages, controls phagocytosis in neutrophils, and mediates inflammatory responses. Only recently have we started to uncover the signaling pathways that cytosolic phospholipase A2 and acid sphingomyelinase are direct intracellular targets of Cer-1-P, and that it may also induce phosphorylation of extracellular signal-regulated kinase-2 and calcium mobilization. These actions of Cer-1-P seem to be cell type-specific.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Gómez-Muñoz Adoi
10.1016/s0014-5793(04)00211-xkeywords:
subject
Has Abstractpub_date
2004-03-26 00:00:00pages
5-10issue
1-3eissn
0014-5793issn
1873-3468journal_volume
562pub_type
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