Abstract:
:Microinjection of human liver mRNA from a patient homozygous for alpha 1-antitrypsin deficiency (PiZZ) into Xenopus oocytes led to a 2--10-fold increase in lysosomal activity. Stimulation of lysosomal activity was not observed when mRNA from a normal human liver (alpha 1-antitrypsin PiMM), or water was injected into the oocyte. This lysosomal activity was oocyte derived and was not due to translation products of the human liver mRNA. Thus a protein that accumulates intracellularly in the secretory pathway is capable of stimulating lysosomal activity.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Bathurst IC,Errington DM,Foreman RC,Judah JD,Carrell RWdoi
10.1016/0014-5793(85)80798-5subject
Has Abstractpub_date
1985-04-22 00:00:00pages
304-8issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(85)80798-5journal_volume
183pub_type
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