Abstract:
:Tissue transglutaminase is a multifunctional enzyme which has been involved in the regulation of cell growth, differentiation, and apoptosis. Recently, nuclear localization of tTG has been reported indicating the potential of active nuclear transport. In this study we use the yeast two-hybrid assay and co-immunoprecipitation to show that tTG interacts with the nuclear transport protein importin-alpha3. Using electron microscopy we demonstrate that nuclear expression of tTG in a non-small cell lung cancer cell line is induced by retinoic acid (RA). These data suggest that importin-alpha3 could mediate active nuclear transport of tTG which may be important for the regulation of critical cellular processes.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Peng X,Zhang Y,Zhang H,Graner S,Williams JF,Levitt ML,Lokshin Adoi
10.1016/s0014-5793(99)00018-6keywords:
subject
Has Abstractpub_date
1999-03-05 00:00:00pages
35-9issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(99)00018-6journal_volume
446pub_type
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