Abstract:
:Using model spontaneously reverting cell lines, c-jun, junB, junD and c-fos oncogene expression was investigated. c-jun, but not junB, junD or c-fos, was overexpressed in highly tumorigenic clones. The reversion of cells to the non-tumorigenic phenotype resulted in a dramatic decrease in c-jun expression. CAT assays revealed that c-jun overexpression in tumorigenic cells was associated with higher transcription activity. No correlation between c-jun oncogene expression and AP-1 transcription factor activity in tumorigenic and non-tumorigenic clones was found.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Lavrovsky Y,Yefremov Y,Lavrovsky Vdoi
10.1016/0014-5793(94)01266-0subject
Has Abstractpub_date
1994-12-19 00:00:00pages
212-4issue
2-3eissn
0014-5793issn
1873-3468pii
0014-5793(94)01266-0journal_volume
356pub_type
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