Abstract:
:CAP (c-Cbl associated protein)/ponsin belongs to a family of adaptor proteins implicated in cell adhesion and signaling. Here we show that CAP binds to and co-localizes with the essential endocytic factor dynamin. We demonstrate that CAP promotes the formation of dynamin-decorated tubule like structures, which are also coated with actin filaments. Accordingly, we found that the expression of CAP leads to the inhibition of dynamin-mediated endocytosis and increases EGFR stability. Thus, we suggest that CAP may coordinate the function of dynamin with the regulation of the actin cytoskeleton during endocytosis.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Tosoni D,Cestra Gdoi
10.1016/j.febslet.2008.12.047subject
Has Abstractpub_date
2009-01-22 00:00:00pages
293-300issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(08)01028-4journal_volume
583pub_type
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