Abstract:
:Farnesoic acid is a signaling molecule that inhibits the transition from budding yeast to filament formation in Candida albicans, but the molecular mechanism regulated by this substance is unknown. In this study, we analyzed the function of CaPHO81, which is induced by farnesoic acid. The pho81Δ mutant cells existed exclusively as filaments under favorable yeast growth conditions. Furthermore, the inhibition of hyphal growth and repression of CPH1, EFG1, HWP1, and GAP1 mRNA expression in response to farnesoic acid were defective in pho81Δ mutant cells. These data suggest a role for CaPHO81 in the inhibition of hyphal development by farnesoic acid.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Chung SC,Kim TI,Ahn CH,Shin J,Oh KBdoi
10.1016/j.febslet.2010.10.026subject
Has Abstractpub_date
2010-11-19 00:00:00pages
4639-45issue
22eissn
0014-5793issn
1873-3468pii
S0014-5793(10)00831-8journal_volume
584pub_type
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