Abstract:
:Liposomes can be loaded with weak acids and bases, which exist in solutions in equilibrium with membrane permeable uncharged form, using various gradients across their membranes. Because in some cases the estimated drug concentration in the loaded liposomes exceeds their aqueous solubility we investigated the physical state of the liposome encapsulated anticancer drug Doxorubicin. X-Ray diffraction, electron microscopy, and test tube solubility experiments have shown that upon encapsulation the drug molecules form a gel-like phase.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Lasic DD,Frederik PM,Stuart MC,Barenholz Y,McIntosh TJdoi
10.1016/0014-5793(92)80947-fkeywords:
subject
Has Abstractpub_date
1992-11-09 00:00:00pages
255-8issue
2-3eissn
0014-5793issn
1873-3468pii
0014-5793(92)80947-Fjournal_volume
312pub_type
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