Abstract:
:Soluble factors derived from human CD8+ T-lymphocytes inhibit HIV-1 replication by suppressing transcription from the viral long terminal repeat (LTR), an effect shown to be mediated in part by an NFAT-1 enhancer sequence. We show here that the CD8+ derived beta-chemokines, RANTES, MIP1-alpha, and MIP-1beta, known suppressors of HIV-1 replication in human peripheral blood mononuclear cells, can suppress transcription from the HIV-1 LTR in transient transfection assays in cells of the Jurkat (acute T leukemia) line. Surprisingly, the suppression mediated by these beta-chemokines persisted in the absence of an intact NFAT-1 element, suggesting that there are at least two classes of HIV-1 suppressor factors--NFAT-1-dependent and NFAT-1-independent factors--produced by CD8+ T-lymphocytes.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Handen JS,Rosenberg HFdoi
10.1016/s0014-5793(97)00654-6subject
Has Abstractpub_date
1997-06-30 00:00:00pages
301-2issue
2-3eissn
0014-5793issn
1873-3468pii
S0014-5793(97)00654-6journal_volume
410pub_type
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