Abstract:
:Two RNA silencing-related phenomena, quelling and meiotic silencing by unpaired DNA (MSUD) have been identified in the fungus Neurospora crassa. Similar to the case with the siRNA and miRNA pathways in Drosophila, different sets of protein components including RNA-dependent RNA polymerase, argonaute and dicer, are used in the quelling and MSUD pathways. Orthologs of the RNA silencing components are found in most, but not all, fungal genomes currently available in the public databases, indicating that the majority of fungi possess the silencing machinery. Advantage and disadvantage of RNA silencing as a tool to explore gene function in fungi are discussed.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Nakayashiki Hdoi
10.1016/j.febslet.2005.08.016keywords:
subject
Has Abstractpub_date
2005-10-31 00:00:00pages
5950-7issue
26eissn
0014-5793issn
1873-3468pii
S0014-5793(05)00995-6journal_volume
579pub_type
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