Abstract:
:Although transthyretin (TTR) is expressed in pancreatic alpha (glucagon) cells in the islets of Langerhans, the function of TTR in pancreatic alpha cells remains unknown. In this study, by using TTR knockout (TTR KO) mice, we determined the novel role of TTR in glucose homeostasis. We demonstrated that TTR KO mice evidenced impaired recovery of blood glucose and glucagon levels. Lack of TTR induced significantly lower levels of glucagon in the islets of Langerhans. These results suggest that TTR expressed in pancreatic alpha cells may play important roles in glucose homeostasis via regulating the expression of glucagon.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Su Y,Jono H,Misumi Y,Senokuchi T,Guo J,Ueda M,Shinriki S,Tasaki M,Shono M,Obayashi K,Yamagata K,Araki E,Ando Ydoi
10.1016/j.febslet.2012.10.025subject
Has Abstractpub_date
2012-11-30 00:00:00pages
4215-22issue
23eissn
0014-5793issn
1873-3468pii
S0014-5793(12)00808-3journal_volume
586pub_type
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