Abstract:
:Chronic inflammation associated with tumor necrosis factor (TNF)-alpha and reactive oxygen species (ROS) is the hallmark of tuberculosis. Mycobacterium tuberculosis (MTB) directly stimulates human monocytes to secrete TNF-alpha. We show the augmented expression of TNF-alpha mRNA in MTB-infected monocytes by cellular activation and ROS was suppressed by allicin in a dose-dependent manner. Also, allicin enhanced the glutathione peroxidase activity, which correlated inversely with the downregulation of ROS and TNF-alpha in MTB-infected monocytes. Hence, allicin may prove to be a valuable natural antioxidant in combating tuberculosis.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Hasan N,Yusuf N,Toossi Z,Islam Ndoi
10.1016/j.febslet.2006.03.071subject
Has Abstractpub_date
2006-05-01 00:00:00pages
2517-22issue
10eissn
0014-5793issn
1873-3468pii
S0014-5793(06)00401-7journal_volume
580pub_type
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