Abstract:
:CXCR2 plays a key role in protecting the integrity of the endothelium. Emerging evidence has demonstrated that the long ncRNAs (lncRNA) Human metastasis associated lung adenocarcinoma transcript 1 (MALAT1) participates in the regulation of the pathophysiological processes. However, whether there is crosstalk between CXCR2 and MALAT1 remains unknown. In this study, we demonstrated that MALAT1 was upregulated in patients with unstable angina. MALAT1 silencing significantly downregulated the expression of the miR-22-3p target gene CXCR2 via reversing the effect of the miR-22-3p, resulting in the aggravation of Oxidized low-density lipoprotein (ox-LDL)-induced endothelial injury; this process was associated with the AKT pathway. Thus, MALAT1 protects the endothelium from ox-LDL-induced endothelial dysfunction partly through competing with miR-22-3p for endogenous RNA.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Tang Y,Jin X,Xiang Y,Chen Y,Shen CX,Zhang YC,Li YGdoi
10.1016/j.febslet.2015.08.046subject
Has Abstractpub_date
2015-10-07 00:00:00pages
3189-96issue
20 Pt Beissn
0014-5793issn
1873-3468pii
S0014-5793(15)00817-0journal_volume
589pub_type
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