Abstract:
:In blood-borne metastasis, intravasated metastatic tumor cells are thought to localize at the target site via a series of processes involving platelet aggregation, adhesion to endothelium, and invasion through the basal membrane. In the present study, we examined how platelet aggregation contributes to the trafficking of metastatic tumor cells in vivo by use of an inhibitor of platelet aggregation. Highly invasive B16BL6 melanoma cells were labeled with [2-18F]2-fluoro-2-deoxy-D-glucose and injected into mice to determine cell trafficking non-invasively by positron emission tomography. Both platelet aggregation inhibitor cyclo(RSarDPhg), which could not inhibit metastasis, and metastatic inhibitor cyclo(GRGDSPA) suppressed the accumulation of B16BL6 cells in the lung by about 12%, suggesting that platelet aggregation partly affects cell trafficking but not to a great extent, and that platelet aggregation is not the essential step for B16BL6 cell arrest in targets.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Koike C,Watanabe M,Isoai A,Kumagai H,Tsukada H,Irimura T,Okada S,Oku Ndoi
10.1016/s0014-5793(98)00441-4subject
Has Abstractpub_date
1998-05-08 00:00:00pages
286-90issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(98)00441-4journal_volume
427pub_type
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