Abstract:
:Two free radical scavengers, bioflavonoid rutin and the copper-rutin complex Cu(Rut)Cl2, inhibited lucigenin-amplified chemiluminescence and lipid peroxidation in rat liver microsomes, Cu(Rut)Cl2 being a 5-9 times more efficient inhibitor than rutin. The enhanced inhibitory activity of Cu(Rut)Cl2 was due to the presence of the additional superoxide-dismutating center (Cu), as follows from the comparison of its effects on microsomal chemiluminescence and cytochrome c reduction by xanthine oxidase. Similar effects of both inhibitors on superoxide production and lipid peroxidation as well as the elevated activity of Cu(Rut)Cl2 indicate an important role of superoxide ion in the initiation of microsomal lipid peroxidation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Afanas'ev IB,Ostrachovich EA,Korkina LGdoi
10.1016/s0014-5793(98)00244-0subject
Has Abstractpub_date
1998-03-27 00:00:00pages
256-8issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(98)00244-0journal_volume
425pub_type
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