Abstract:
:Interrogation of the Human Genome data for sequences related to the von Willebrand factor A-domain module identified a previously unreported 4.1 kb full-length cDNA that is predicted to encode a new member of the collagen superfamily of extracellular matrix proteins, collagen XXI. The domain organization of collagen XXI comprised an N-terminal signal sequence, followed by single von Willebrand factor A-domain and thrombospondin domains, and an interrupted collagen triple helix. The organization of these motifs predict that collagen XXI is a new member of the FACIT collagen sub-family. Expression analysis indicated that COL21A1 mRNA is present in many tissues including heart, stomach, kidney, skeletal muscle and placenta, and radiation hybrid mapping localized the COL21A1 gene to 6p11-12.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Fitzgerald J,Bateman JFdoi
10.1016/s0014-5793(01)02754-5keywords:
subject
Has Abstractpub_date
2001-09-14 00:00:00pages
275-80issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(01)02754-5journal_volume
505pub_type
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