Abstract:
:Targeting of preproteins to mitochondria and their translocation across the outer membrane are mediated by the mitochondrial receptor complex. This protein complex contains the import receptors MOM19 and MOM72 and the general insertion pore GIP. All seven components of the receptor complex are synthesized in the cytosol and thus have to be targeted to the mitochondria themselves. Here we investigated the import pathway of the precursor of MOM22 into the outer membrane. In contrast to other mitochondrial preproteins studied so far, the import of MOM22 absolutely depended on the presence of surface receptors. In fact, both receptors MOM19 and MOM72 were involved in its import pathway. The targeting of MOM22 to mitochondria is thus highly specific and controlled.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Keil P,Pfanner Ndoi
10.1016/0014-5793(93)80107-6subject
Has Abstractpub_date
1993-04-26 00:00:00pages
197-200issue
2-3eissn
0014-5793issn
1873-3468pii
0014-5793(93)80107-6journal_volume
321pub_type
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