Abstract:
:SARS 8b is one of the putative accessory proteins of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) with unknown functions. In this study, the cellular localization and activity of this estimated 9.6 kDa protein were examined. Confocal microscopy results indicated that SARS 8b is localized in both nucleus and cytoplasm of mammalian cells. Functional study revealed that overexpression of SARS 8b induced DNA synthesis. Coexpression of SARS 8b and SARS 6, a previously characterized SARS-CoV accessory protein, did not elicit synergistic effects on DNA synthesis.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Law PY,Liu YM,Geng H,Kwan KH,Waye MM,Ho YYdoi
10.1016/j.febslet.2006.05.051subject
Has Abstractpub_date
2006-06-26 00:00:00pages
3643-8issue
15eissn
0014-5793issn
1873-3468pii
S0014-5793(06)00664-8journal_volume
580pub_type
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