Abstract:
:Retinoic acid receptor-related orphan receptor-alpha (RORalpha) is a nuclear orphan receptor. Adenovirus-mediated overexpression of RORalpha1 and RORalpha4 suppressed tumor necrosis factor-alpha (TNF-alpha)-induced expression of vascular cell adhesion molecule-1 (VCAM-1) and intracellular adhesion molecule-1 (ICAM-1) in human umbilical vein endothelial cells. Overexpression of RORalpha1 and RORalpha4 also suppressed TNF-alpha-stimulated translocation of p50 and p65 to the nucleus. In contrast, dominant-negative deletion mutants of RORalpha1 and RORalpha4 failed to suppress the induction of VCAM-1 and ICAM-1 and translocations of p50 and p65. These results suggest that RORalpha1 and RORalpha4 regulate the inflammatory responses via inhibition of the nuclear factor-kappaB signaling pathway in endothelial cells.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Migita H,Satozawa N,Lin JH,Morser J,Kawai Kdoi
10.1016/s0014-5793(03)01502-3keywords:
subject
Has Abstractpub_date
2004-01-16 00:00:00pages
269-74issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579303015023journal_volume
557pub_type
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