RORalpha1 and RORalpha4 suppress TNF-alpha-induced VCAM-1 and ICAM-1 expression in human endothelial cells.

Abstract:

:Retinoic acid receptor-related orphan receptor-alpha (RORalpha) is a nuclear orphan receptor. Adenovirus-mediated overexpression of RORalpha1 and RORalpha4 suppressed tumor necrosis factor-alpha (TNF-alpha)-induced expression of vascular cell adhesion molecule-1 (VCAM-1) and intracellular adhesion molecule-1 (ICAM-1) in human umbilical vein endothelial cells. Overexpression of RORalpha1 and RORalpha4 also suppressed TNF-alpha-stimulated translocation of p50 and p65 to the nucleus. In contrast, dominant-negative deletion mutants of RORalpha1 and RORalpha4 failed to suppress the induction of VCAM-1 and ICAM-1 and translocations of p50 and p65. These results suggest that RORalpha1 and RORalpha4 regulate the inflammatory responses via inhibition of the nuclear factor-kappaB signaling pathway in endothelial cells.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Migita H,Satozawa N,Lin JH,Morser J,Kawai K

doi

10.1016/s0014-5793(03)01502-3

keywords:

subject

Has Abstract

pub_date

2004-01-16 00:00:00

pages

269-74

issue

1-3

eissn

0014-5793

issn

1873-3468

pii

S0014579303015023

journal_volume

557

pub_type

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