Abstract:
:We tested the truncated 7-37 glucagon-like peptide 1 (TGLP-1), a naturally occurring porcine intestinal peptide, and other members of the glucagon family, including pancreatic glucagon (G-29), GLP-1 and GLP-2 for their ability to activate the cAMP generating system in rat gastric glands and HGT-1 human gastric cancer cells. In rat fundic glands, TGLP-1 was about 100 times more potent (EC50 = 2.8 X 10(-9) M) than GLP-1 of G-29, and 10 times more potent than G-29 in the HGT-1 cell line. Our results support the notion that TGLP-1 plays a direct role in the regulation of acid secretion in rat and human gastric mucosa.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Hansen AB,Gespach CP,Rosselin GE,Holst JJdoi
10.1016/0014-5793(88)80297-7subject
Has Abstractpub_date
1988-08-15 00:00:00pages
119-22issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(88)80297-7journal_volume
236pub_type
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