Abstract:
:Ca(2+) entering cells through store-operated channels (SOCs) affects most cell functions, and excess SOC is associated with pathologies. The molecular makeup of SOCs and their mechanisms of gating were clarified with the discovery of the Orais and STIM1. Another form of SOCs are the TRPCs. STIM1 gates both Orai and TRPC channels but does so by different mechanisms. Although the STIM1 SOAR domain mediates the binding of STIM1 to both channel types, SOAR is sufficient to open the Orais but the STIM1 polylysine domain mediates opening of the TRPC channels. This short review discusses recent findings on how STIM1 gates and regulates the Orais and TRPCs, and how the STIM1/Orai1/TRPCs complexes may function in vivo to mediate SOC activity.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Lee KP,Yuan JP,Hong JH,So I,Worley PF,Muallem Sdoi
10.1016/j.febslet.2009.11.078subject
Has Abstractpub_date
2010-05-17 00:00:00pages
2022-7issue
10eissn
0014-5793issn
1873-3468pii
S0014-5793(09)00995-8journal_volume
584pub_type
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