Abstract:
:Human high- and low-Mr kininogens were shown to be potent inhibitors of cysteine proteinases such as cathepsin L and papain (Ki = 17-48 pM). A strong immunological cross-reaction between the kininogens and low-Mr alpha-cysteine proteinase inhibitor from human plasma was found. Comparison of partial amino acid sequences from high- and low-Mr kininogen and low-Mr alpha-cysteine proteinase inhibitor demonstrated sequence identity for all segments analyzed. These findings suggest that the kininogens and the alpha-cysteine proteinase inhibitors from human plasma are identical proteins.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Müller-Esterl W,Fritz H,Machleidt W,Ritonja A,Brzin J,Kotnik M,Turk V,Kellermann J,Lottspeich Fdoi
10.1016/0014-5793(85)80322-7subject
Has Abstractpub_date
1985-03-25 00:00:00pages
310-4issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(85)80322-7journal_volume
182pub_type
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