Primary and post-irradiation inactivation of the sulfhydryl enzyme malate synthase: correlation of protective effects of additives.

Abstract:

:The presence of additives during X-irradiation of malate synthase led to radioprotective effects against primary and post-irradiation inactivation. Pronounced effects were provided by typical scavengers, sulfhydryl reagents and specific ligands (substrates, products, analogues). The results show that scavenging and specific protection are responsible for the protective efficiency of additives. Scavengers delete noxious species formed during irradiation or post-radiationem. Sulfhydryl reagents may act as repair substances. Specific ligands protect the active site of the enzyme and the essential sulfhydryls; specific protection is more pronounced post-radiationem. Ligands and sulfhydryl reagents may additionally act as scavengers. A cumulative index for the protective power of additives against both sorts of inactivation was established.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Durchschlag H,Zipper P

doi

10.1016/0014-5793(88)80203-5

subject

Has Abstract

pub_date

1988-09-12 00:00:00

pages

208-12

issue

1-2

eissn

0014-5793

issn

1873-3468

pii

0014-5793(88)80203-5

journal_volume

237

pub_type

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