Abstract:
:Islet-activating protein (IAP) suppressed Ca2+-induced histamine release and phospholipase A2 activation in Gpp(NH)p-loaded mast cells. Since the guanine nucleotide-binding protein involved in adenylate cyclase inhibition is known to lose its function upon being ADP-ribosylated by IAP, the nucleotide-binding protein is likely to mediate Ca2+-linked biosignalling leading to histamine secretion.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Nakamura T,Ui Mdoi
10.1016/0014-5793(84)80816-9subject
Has Abstractpub_date
1984-08-06 00:00:00pages
414-8issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(84)80816-9journal_volume
173pub_type
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