Abstract:
:E. coli trigger factor is an abundant cytosolic protein originally identified by its ability to maintain the precursor of a secretory protein in a translocation competent form. Recent studies shed new light on the function of this protein. Trigger factor was found to be a peptidyl-prolyl-cisltrans-isomerase capable of catalysing protein folding in vitro, to associate with nascent cytosolic and secretory polypeptide chains, and to cooperate with the GroEL chaperone in promoting proteolysis of an unstable polypeptide in vivo. These findings suggest roles for trigger factor in various folding processes of secretory as well as cytosolic proteins.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Hesterkamp T,Bukau Bdoi
10.1016/0014-5793(96)00582-0subject
Has Abstractpub_date
1996-06-24 00:00:00pages
32-4issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(96)00582-0journal_volume
389pub_type
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